Letter: Bence Jones lambda plasma cell myeloma

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Intranuclear inclusions in Bence Jones lambda plasma cell myeloma.

A patient with plasma cell myeloma producing only Bence Jones lambda protein was found to have pale intranuclear inclusions in the majority of the bone marrow plasma cells. These inclusions, previously undescribed in myeloma patients producing only Bence Jones protein, contained Bence Jones lambda protein, were non-electron dense, bound by a single membrane, and contained no cytoplasmic structu...

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Bence Jones myeloma with signet-ring-like plasma cells.

Signet-ring cells, typical of muciparous adenocarcinoma, are seldom observed in other solid tumors or in lymphoproliferative disorders. Two cases of myeloma with signet-ring morphology have been reported so far. To the best of our knowledge, the following is the first case of signetring cell Bence-Jones myeloma. A 69-year-old man presented with cachexy, dehydration, liver enlargement and multin...

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Bence Jones proteinuria and myeloma kidney.

Bence-Jones proteinuria refers to urinary excretion of monoclonal light chains. It results from exclusive production of one light chain, or the unbalanced synthesis of heavy and light chains, with the latter being in excess. Free Kor A-light chains are therefore excreted alone or in addition to complete immunoglobulin molecules carrying the same light chain type. Free light chains are low molec...

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Bence Jones myeloma cells with crystalline inclusions.

A 40-year-old man was found to have proteinuria on a routine medical checkup in 1993. Further examination showed an erythrocyte sedimentation rate of 7 mm/h, hemoglobin 15.1 g/dL, white cell count 3,400/mm, platelet count 175,000/mm, IgG 366 mg/dL, IgA 11 mg/dL, IgM 10 mg/dL, blood urea nitrogen 25 mg/dL, and creatinine 1.2 mg/dL. Immunoelectrophoresis revealed Bence Jones protein (к light chai...

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Melphalan and Antigenic Type of Bence-jones Proteins in Myeloma.

averaged many times (up to 100 times) a peak of activity could sometimes be observed to correspond with the minimum or the maximum intensity of light, according to the cell type ("off cells" or "on cells," respectively). The shape of the response, however, remained completely chaotic. An example of these results is shown in Fig. 1. Control experiments showed that the response of the retinal gan...

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ژورنال

عنوان ژورنال: Blood

سال: 1975

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v46.4.652.bloodjournal464652